25 Apr Stem Cells For Hair Loss
What are stem cells?
These are totipotent cells. Stem cells have a marvelous potential to differentiate into many types of cells in the body. Each divided cell has the potential to remain a stem cell or become any other type of cell with a particular function as per the necessity in any tissue or body part.
What is stem cell therapy?
Stem cell therapy is the use of stem cells to treat any health condition or disease. Bone marrow transplant is a commonly used stem cell therapy. Now stem cell therapies derived from umbilical cord blood are also in use and gradually gaining popularity. Stem cell therapies have been proved to treat a number of conditions.
Can stem cells prevent hair loss?
Hair loss or baldness is a huge problem for everyone. There are numbers of hair transplant or other treatments available to treat hair loss which may have many side effects. Stem cell therapy is an effective hair loss treatment. This is a very adept and non-surgical hair therapy in which your own stem cells are used to enhance hair follicle growth. Progressive loss of stem cells in hair follicles may cause baldness or hair loss. Stem cells are present in the middle of the hair follicle and ensure the constant supply of cells. So it helps in generating hair cells promptly treating baldness or hair loss. Stem cells not only help to avert hair loss but also upgrade the texture and quality of hair. Stem cell therapy is certainly safe and has no side effects.
How is stem cell therapy performed?
The doctor collects hair follicles. These are enlightened and processed in the laboratory to yield more stem cells. After 15 to 20 days doctor implants the hair on the scalp. Stem cells when combined with existing cells they multiply and encourage hair growth process. Stem cells spark the dead hair follicles and convert them into healthy follicles. They stimulate the sluggish hair follicles and allow them to grow again. The number of required sessions depends on the amount and stage of hair loss.
Stem cell hair transplant side effects
There’s very little information available about the possible side effects of stem cell hair transplants. As with any medical procedure, there’s always the risk of bleeding or infection at the site of the sample and the injection. Scarring is also possible. Though complications from a punch biopsy are rare, there’s a small risk of damage to the nerves or arteries beneath the site. Liposuction can also cause the same side effects and complications.
Stem cell hair transplant success rate
The research available on the success rate of stem cell hair transplants is very promising. The results of the Italian study showed a 29 percent Trusted Source increase in hair density 23 weeks after the last treatment. The clinics that currently offer stem cell hair therapies not approved by the FDA don’t make any guarantees regarding to results or success rates.
Stem cell hair transplant cost
The cost of stem cell hair transplants hasn’t been determined since they’re still in the research stages. Some of the investigational stem cell hair replacement therapies being offered by various clinics range from approximately $3,000 to $10,000. Final cost depends on the type and extent of the hair loss being treated.
The stem cell hair transplant treatments being researched are expected to be available to the public by 2020. Stem cell hair transplants offer options to people who aren’t candidates for the hair loss treatments currently available. While some clinics are offering stem cell hair replacement therapies, these are considered investigational and haven’t been approved by the FDA.
How Are Stem Cell Treatments Different From PRP (Platelet Rich Plasma) Treatments?
PRP stands for Platelet Rich Plasma. It begins with centrifuging blood so we can concentrate the growth factors and platelets naturally present.PRP does not provide much stem cells because adults typically don’t have many stem cells in our blood. In contrast, Mesenchymal Stem Cells from the human umbilici cord are stem cells, not just growth factors. When injected into the scalp these cells can help to promote hair growth. Stem cell injections as a treatment for hair loss began with physicians concentrating human stem cells from the fat harvested during liposuction, then injecting the stem cells into either the face (for facial rejuvenation) or the scalp to combat hair loss. The issue with sourcing stem cells from fat is that the stem cells are not always high quality or as potent and powerful, especially as patients get older. Therefore, we have chosen to use stem cells from the human umbilical cord, which usually are more robust and potent when they are compared to the stem cells derived from fat cells.
New Stem Cell-Based Topical Solution Helps Bald People Regrow Hair
The results of a clinical trial released today (May 18, 2020) in STEM CELLS Translational Medicine demonstrate how a topical solution made up of stem cells leads to the regrowth of hair for people with a common type of baldness.
Androgenetic alopecia (AGA) — commonly known as male-pattern baldness (female-pattern baldness in women) — is a condition caused by genetic, hormonal and environmental factors. It affects an estimated 50 percent of all men and almost as many women older than 50. While it is not a life-threatening condition, AGA can lower a person’s self-esteem and psychological well-being. There are a few FDA-approved medications to treat hair loss, but the most effective can have side effects such as loss of libido and erectile dysfunction. Therefore, the search continues for a safer, effective treatment.
Adipose tissue-derived stem cells (ADSCs) secrete several growth hormones that help cells develop and proliferate. According to laboratory and experimental studies, growth factors such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF) and platelet-derived growth factor (PDGF) increase the size of the hair follicle during hair development.
How did the team produce the stem cells?
The researchers converted the human skin cells into induced pluripotent stem cells (iPSCs) by adding three genes. These iPSCs are able to change into any cell types in the body, so the researchers converted them into epithelial stem cells, which are normally found in a part of hair follicles.
Using techniques from other research teams to convert iPSCs into keratinocytes – a main cell type in the top layer of the skin – Dr. Xu and colleagues showed they could “force” the iPSCs to make large quantities of EpSCs by controlling the timing of growth factors the cells received. Medically reviewed by Brett E. Glotzbecker, MD
WHAT IS A STEM CELL TRANSPLANT?
A stem cell transplant is an infusion of healthy stem cells. Stem cells are located within the bone marrow and are the cells from which all other blood cells and the immune system are created. There are several side effects that patients may experience as they undergo stem cell transplantation. Here are the side effects that may occur during the conditioning process, which prepares your immune system for the stem cell transplant, as well as how you may feel during and immediately after the infusion of new stem cells.
To prepare for a stem cell transplant, you will go through conditioning treatment, which may include chemotherapy and/or radiation. Side effects of conditioning may include mouth sores, nausea and vomiting, diarrhea, fatigue, dry mouth, hair loss, rashes and breathing problems.
Stem Cell Infusion
After conditioning comes the actual stem cell infusion, when you will receive your new stem cells. The most common side effects during stem cell infusion are fevers, headaches, chills, flushing, and nausea at the end of the infusion — which can occur up to one hour after the stem cell infusion is completed. In some cases, intravenous fluids or medication can be given to help prevent or reduce these effects.
The phase after the stem cell infusion is called engraftment, when the transplanted stem cells begin to make new blood components — including red blood cells, platelets, and other components of the immune system — within your body. From the time you receive stem cells until engraftment, you may experience side effects including nausea, and trouble sleeping. You may also develop skin rashes, as well as mucositis, which makes it difficult to eat or drink. Diarrhea and lack of appetite are also common. Most patients are very tired and get warn out with very little activity while their counts are low. Some of these side effects may persist for a period of time even after you return home.
The most common side effects after transplant are fatigue, lack of appetite, diarrhea, nausea, and vomiting. Many patients also continue to deal with hair loss, skin rash, swelling, weight loss or gain, fatigue, change in taste/appetite, or decrease in sexual desire. For allogeneic transplant patients, it is important to be aware of possible signs of graft-versus-host disease (GVHD), which may include skin rashes or skin changes, yellowing of the skin or eyes, excessive dryness or pain in the mouth, joint pain, or eye dryness.
It is important to share information about the side effects that you experience with your care team. With time, many of these side effects subside as your immune system recovers.